Open Access News

News from the open access movement

Sunday, June 03, 2007

Report on an OA database

Jyoti K. Shah and four co-authors, sIR: siRNA Information Resource, a web-based tool for siRNA sequence design and analysis and an open access siRNA database, BMC Bioinformatics, May 31, 2007.  Excerpt from the provisional abstract:  

RNA interference has revolutionized our ability to study the effects of altering the expression of single genes in mammalian (and other) cells through targeted knockdown of gene expression. In this report we describe a web-based computational tool, siRNA Information Resource (sIR), which consists of a new open source database that contains validation information about published siRNA sequences and also provides a user-friendly interface to design and analyze siRNA sequences against a chosen target sequence....