Open Access News

News from the open access movement


Friday, May 12, 2006

More on the upcoming launch of PLoS Clinical Trials

David Grimm, A Cure for the Common Trial, Science Magazine, May 12, 2006 (accessible only to subscribers). Excerpt:
Ordinarily, a study with negative results...wouldn’t see the light of day in a medical journal --at least not a top-tier one. But the Public Library of Science (PLoS) aims to be different. It’s using the LOTIS study [showing that certain interventions do not slow the onset of age-related disabilities] to launch its new journal, PLoS Clinical Trials, which begins publishing on 19 May. The journal’s credo is simple: Disappointing results can still be good news. Its editors have explicitly stated that all clinical trials submitted --regardless of outcome or significance-- will be published, as long as they are methodologically sound. The policy takes aim at a pervasive problem in the clinical trials literature: a heavy skew toward studies with positive outcomes. Some say there’s a “black hole” where studies with negative or ambiguous outcomes should be. This bias can cost lives....