The only thing separating mankind from a pandemic that could kill 150 million people are a few changes in the RNA of the H5N1 avian 'flu virus. Those changes would make it easier for the virus to infect and pass between humans, rather than birds....The good news is that with modern sequencing technologies it is possible to track those changes as they happen, and to use this information to start preparing vaccines that are most likely to be effective against any eventual pandemic virus....The bad news is that most of those vital sequences are being kept hidden away by the various national laboratories that produce them. As a result, thousands of scientists outside those organisations do not have the full picture of how the H5N1 virus is evolving, medical communities cannot plan properly for a pandemic, and drug companies are hamstrung in their efforts to develop effective vaccines. The apparent reason for the hoarding - because some scientists want to be able to publish their results in slow-moving printed journals first so as to be sure that they are accorded full credit by their peers - beggars belief against a background of growing pandemic peril. Open access to data never looked more imperative.
Although the calls to release this vital data are gradually becoming more insistent, they still seem to be falling on deaf ears. One scientist who has been pointing out longer than most the folly of the current situation is the respected researcher Harry Niman. He has had a distinguised career in the field of viral genomics, and is the founder of the company Recombinomics. The news section of this site has long been the best place to find out about the latest developments in the field of avian 'flu. This is for three reasons: Niman's deep knowledge of the subject, his meticulous scouring of otherwise-neglected sources to find out the real story behind the news, and - perhaps just as important - his refusal meekly to tow the line that everything is under control. For example, he has emphasised that the increasing number of infection clusters indicates that human-to-human transmission is now happening routinely, in flat contradiction to the official analysis of the situation....Let's hope for the sake of everyone that WHO and the other relevant organisations see the light and start making all the genomic data available. This would allow Niman and his many able colleagues to monitor even the tiniest changes, so that the world can be alerted at the earliest possible moment to the start of a pandemic that may be closer than many think.
Posted by
Peter Suber at 3/15/2006 08:22:00 AM.
The open access movement:
Putting peer-reviewed scientific and scholarly literature
on the internet. Making it available free of charge and
free of most copyright and licensing restrictions.
Removing the barriers to serious research.
I recommend the OA tracking project (OATP) as the best way to stay on top of new OA developments. You can read the OATP feed on a blog-like web page or subscribe to it by RSS, email, or Twitter. You can also help build the feed by tagging new developments you encounter.
