Maria Gaetana Agnesi (1719-1799) was an Italian mathematician who did some of the earliest pioneering work in calculus. She was a gifted scholar from very early in her life, and by the age of 20 was a well-published scientist. She is credited with writing the first comprehensive textbook and reference source on calculus, called Instituzioni analitiche (shown in the photo above). According to historical accounts, her primary reason for writing the book was to teach her brother calculus! She was the eldest of 20 siblings, and became the primary caretaker of their household after they lost their mother when Maria was still fairly young. The graph above shows a famous curve that has come to be known as the "Witch of Agnesi." It is named after Maria Agnesi.

There are several websites that provide further details of Maria Agnesi's work and biography. Here are a couple, for starters:

        https://www.smithsonianmag.com/smart-news/witch-agnesi-180963221/
        http://jwilson.coe.uga.edu/Texts.Folder/Agnesi/witch.html